Certain common herbs possess MAO inhibitor activity, requiring caution when combined with other substances. While Zoloft is often questioned, it belongs to a different class of antidepressants than MAOIs.
MAOs, or monoamine oxidases, are enzymes that break down neurotransmitters and stop their messaging activity. MAO-A breaks down serotonin, epinephrine and norepinephrine; MAO-B deactivates dopamine.
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With the wide variety of drugs available for depression and anxiety, it can be hard to know which drugs fall into which class, and what the accompanying effects are. Zoloft is not an MAO inhibitor but is a selective serotonin reuptake inhibitor (SSRI).
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