Many people experience leg cramps while driving, especially when driving long distances. A variety of muscle injuries can cause leg cramps, so consult your doctor before trying home remedies. Leg cramps also are occasionally caused by insufficient potassium and dehydration, according to the "

The American Academy of Orthopaedic Surgeons reports that a deficiency in electrolytes like potassium can cause muscle cramps, particularly in your legs. This can occur frequently in the summer, when heat causes you to lose salt and other minerals through your sweat.